Myocardial Remodeling and Fibrosis
Heart failure progression involves structural and functional changes in the myocardium, including remodeling and fibrosis.
Key Highlights:
- Mechanism: Chronic pressure/volume overload triggers myocyte hypertrophy and extracellular matrix deposition.
- Clinical impact: Reduced contractility, arrhythmias, and worsening heart failure.
- Diagnosis: Imaging techniques such as MRI and echocardiography assess fibrosis.
- Therapeutic targets: ACE inhibitors, beta-blockers, and novel antifibrotic agents.
- Prognosis: Early intervention slows remodeling, improving survival and functional status.
Targeting myocardial remodeling is a cornerstone in preventing heart failure progression.
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