9^th World Congress On Cardiology and Heart Failure

Myocardial Remodeling and Fibrosis

Heart failure progression involves structural and functional changes in the myocardium, including remodeling and fibrosis.

Key Highlights:

• Mechanism: Chronic pressure/volume overload triggers myocyte hypertrophy and extracellular matrix deposition.
• Clinical impact: Reduced contractility, arrhythmias, and worsening heart failure.
• Diagnosis: Imaging techniques such as MRI and echocardiography assess fibrosis.
• Therapeutic targets: ACE inhibitors, beta-blockers, and novel antifibrotic agents.
• Prognosis: Early intervention slows remodeling, improving survival and functional status.

Targeting myocardial remodeling is a cornerstone in preventing heart failure progression.