Heart Failure with Preserved Ejection Fraction Challenges

Heart failure with preserved ejection fraction (HFpEF) poses diagnostic and therapeutic challenges due to heterogeneity in pathophysiology.

Key Highlights:

  • Diagnosis: Echocardiography and biomarkers aid in differentiating HFpEF from other cardiac conditions.
  • Comorbidities: Hypertension, diabetes, obesity, and atrial fibrillation complicate management.
  • Symptom management: Diuretics relieve congestion; exercise and lifestyle modification improve functional status.
  • Novel therapies: Clinical trials explore SGLT2 inhibitors, mineralocorticoid receptor antagonists, and personalized medicine.
  • Prognosis: Early identification and multidisciplinary management enhance quality of life and reduce hospitalizations.

Addressing HFpEF requires individualized care focusing on underlying causes and symptomatic improvement.

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